Marble Burying Compulsive Behavior

When put in a cage with marbles mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging while mice with a high degree of anxiety tend to engage in a high degree of digging in.

Marble burying compulsive behavior. Hallmark features of ocd patients are similarities and more prominent differences from anxiety disorders e g the absence of sex differences and resistance to spontaneous remission. Both tests take advantage of the fact that the target behaviors occur spontaneously in mice. The marble burying behavior test is an acute test. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding.

While widely used there is significant controversy over the interpretation of its results. Perhaps the animal models with the greatest validity and ease of use are the marble burying test and the nestlet shredding test. However some investigators incorporate the sub acute treatment regimen as an essential component for screening anti compulsive agents. Disease head injury genetic modifications and treatment of mice with drugs can have profound effects on behavior.

Numerous animal models for evaluating compulsive like behaviors have been developed over the past three decades. Marble burying is an animal model used in scientific research to depict anxiety or obsessive compulsive disorder ocd behavior. Large nest building lnb and high marble burying hmb which may be relevant to understanding the neurobiology of different symptom dimensions in obsessive compulsive and related disorders. This study aimed to further dissect the deer mouse peromyscus maniculatus bairdii model of compulsive like behavior with respect to two persistent like behavioral phenotypes viz.

Marble burying is considered an albeit controversial animal model of the compulsive like behaviors of obsessive compulsive disorder ocd. Utilizing well characterized and validated approaches such as marble burying and nestlet shredding compulsive like behaviors can be documented accurately in mice as models of human obsessive compulsive disorder and autism spectrum disorder. However modulation of marble burying by serotonin reuptake inhibitors prompted its link to obsessive compulsive disorder compulsive like behavior. Both tests show excellent face construct and predictive validity for the human disorders they model 6 11.

Considered together with the results from. Hallmark features of ocd patients are similarities and more prominent differences from anxiety disorders e g the absence of sex differences and resistance to spontaneous remission. Marble burying is considered an albeit controversial animal model of the compulsive like behaviors of obsessive compulsive disorder ocd.