Marble Burying Difficulty

Marble burying as a model of obsessive compulsive disorder.

Marble burying difficulty. Marble burying is an animal model used in scientific research to depict anxiety or obsessive compulsive disorder ocd behavior. It has been shown to be sensitive to benzodiazepines as these compounds reduce burying behaviour when. Mice which are placed individually in a cage bury glass marbles that are present in the cage. Marble burying sptm duration.

It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. While widely used there is significant controversy over the interpretation of its results. The number of marbles that were buried by the mouse was measured. The marble burying test is used to record the number of marbles buried by mice placed in a novel environment.

This test has some predictive value for anti depressant and or anxiolytic drugs. It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19. The marble burying test typically involves the use of a cage with clean bedding and therefore it is reasonable to question how these three behaviors might affect marble burying behavior. Other than the specific studies mentioned above the chief objection while modeling ocd in animals is the difficulty in assessing obsessions because their detection depends on verbal or written communications.

Marble burying the marble burying test is a useful model of neophobia 1 anxiety 1 7 and obsessive compulsive behavior 8 11. Each mouse was placed for 45 min into a clean rat cage with 4 cm deep bedding and 12 glass marbles placed on the surface. In december 2007 aquino experienced periodic fluctuations of blood pressure difficulty in breathing hair loss loss of appetite and a remarkable drop in weight some days after her physician informed the aquino family that she had vaginal cancer and by mid march 2008 she confided the nature of her disease to a close friend rev catalino arévalo. The behavioral tests were conducted in increasing order of difficulty and stress ranging from marble burying social interaction and y maze choice arm reversal.

Neurodevelopmental disorders including intellectual disability and autism spectrum disorder are often caused by de novo autosomal dominant mutations. Since the burying of any object must involve the displacement of bedding material to cover that object the most reasonable assumption is that of these three. Amit page recommended for you.